Colistin Sulfate Soluble Powder

Generic name: Colistin Sulfate Soluble Powder

Commodity name: shuchang

English Name: Colistin Sulfate Soluble Powder

Chinese Pinyin: Liusuan Nianjunsu Kerongxingfen

[Main ingredients] Colistin

[Character] This product is white or similar white powder

[Pharmacological action] Pharmacodynamics  Colistin is peptide antibiotics, is a kind of cationic surface active agent, through and within the bacterial cell membrane phospholipid interactions, penetrate into the bacterial cell membrane, destruction of the structure, and cause the change of the permeability of membrane, causing the death of bacteria, produce a bactericidal effect.Gram negative bacteria, aerobic bacteria, Escherichia coli, Haemophilus influenzae, Klebsiella, Pasteurella multocida, Pseudomonas aeruginosa, Salmonella, Shigella, the product has strong antimicrobial effects.The bacteria were sensitive to polymyxin little resistance.Proteus and most of Serratia is not affected by colistin.Gram positive bacteria are usually not sensitive.

Pharmacokinetic study  Oral administration is hardly absorbed, but non gastrointestinal administration is absorbed rapidly.The drug into the body can be quickly distributed into the heart, liver, lungs, kidneys and skeletal muscle, but not easy to enter the brain spinal cord, chest, joint cavity and infectious lesions.Mainly through renal excretion.

[Drug interactions](1)It has a synergistic effect with the zinc 1:5.

(2)the combination of neuromuscular blockade with neuromuscular blocking agents may cause muscle weakness and apnea.

(3) with the chelating agent (EDTA) and cationic cleaning agent for Pseudomonas aeruginosa has a synergistic effect, often combined with the treatment of local infection

(4) a combination of drugs that can damage the kidney function can enhance its renal toxicity.

[Indications] For preventing pig, chicken gram negative bacteria caused by intestinal infection, such as yellow scour of newborn piglets, white scour of piglets, piglet paratyphoid, pullorum disease, Chicken Colibacillosis.

[Usage and dosage] According to the product.Mix drink: every 1L water, chicken 0.4-1.2g; mix feed: pig, every 1kg feed, 0.8-1.6g

[Adverse reaction] Slime carotenoid in oral or topical administration of animals can be tolerated, systemic application may cause nephrotoxicity, neurotoxicity and neuromuscular blocking effect, colistin toxicity than polymyxin B.

[Note](1) the laying period of laying hens is disabled.

(2) continuous use should not be more than a week.

[Withdrawal period]Pig, chicken seven days

[Specification] 5% (150 million mycetozoan unit)

[Packing]100g/bottle

[Storage] Shading, airtight, preserved in the dry place